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KMID : 0848120050300040117
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International Journal of Oral Biology
2005 Volume.30 No. 4 p.117 ~ p.123
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Antioxidant Property of Vitamin C-in Comparison with Vitamin B1
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Seo Du-Kyo
Kim Jeong-Hee
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Abstract
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Various aspects of antioxidant activity in vitamin C were evaluated in this study. Relatively high level of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was detected in vitamin C, but not in non-antioxidative vitamin, vitamin B1. Vitamin C also reduced the production of lipid peroxidation in Chinese hamster lung fibroblast (V79-4) cells with IC50 value of 4 ㎍/ml. Vitamin B1 showed comparable reduction in lipid peroxidation products (IC50 value was about 10㎍/ml). It was shown that vitamin C also dose-dependently enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in V79-4 cells, and these effects were not observed in vitamin Bl-treated cells. Our data suggest that well-known antioxidant vitamin C involved in direct activation of SOD, CAT and GPX.
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KEYWORD
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Vitamin C, Radical scavenging, Lipid peroxidation, Antioxidant enzymes
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